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Understanding Metastatic Colorectal Cancer (mCRC): Causes, Prevalence, and Treatment | Takeda Oncology

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Metastatic Colorectal Cancer (mCRC)


Metastatic colorectal cancer (mCRC) can also be referred to as advanced colon cancer or stage 4 colon cancer.1 Metastases – cancer cells that break away from the original tumor, spread through the bloodstream or lymphatic system and form new tumors on different organs – are the main cause of CRC-related mortality. 2,3

mCRC is a highly heterogeneous disease, meaning the disease can affect each patient differently. Given this, there is not a “one-size-fits-all” approach for treatment. Treatment planning and sequencing is critical to ensure patients have the chance to receive all available treatment options.4


1Memorial Sloan Kettering Cancer Center. Treatment for Metastatic Colon Cancer. Available at: https://www.mskcc.org/cancer-care/types/colon/treatment/metastases 2City of Hope Cancer Treatment Centers. Metastatic Colorectal Cancer (stage 4). Available at: https://www.cancercenter.com/cancer-types/colorectal-cancer/types/metastatic-colorectal-cancer 3Vatandoust S, et al. World J Gastroenterol. 2015;21(41):11767-76. 4Loupakis F, Antonuzzo L, Bachet JB, et al. Practical considerations in the use of regorafenib in metastatic colorectal cancer. Ther Adv Med Oncol 2020;12:1758835920956862.

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